-0.5 C
New York
Monday, January 5, 2026
Home Blog Page 9

Motion Sickness Vomiting Prevention Drug Gets Approval

0

Millions of Americans can now look forward to a better time traveling, with the US Food and Drug Administration (FDA) approving a novel oral pill that helps prevent motion-induced vomiting – the first of its kind in more than 40 years.

Tradipitant, an oral neurokinin-1 (NK-1) receptor antagonist made by Vanda Pharmaceuticals – to be sold under the brand name Nereus – is a landmark development for motion sickness treatment.

“For the first time in over 40 years, patients have access to a novel therapy grounded in modern neuropharmacology, offering effective prevention without the limitations of existing options,” said Vanda’s CEO Mihael Polymeropoulos in a statement.

Motion sickness affects up to 30% of adults and can make travel incredibly unpleasant. Traditional options, including some antihistamines, have been the main interventions for nearly half a century, despite limited effectiveness and side effects such as drowsiness.

Nereus works by blocking the NK-1 receptor in the brainstem – implicated in the vomiting reflex that responds to a neurotransmitter called substance P. By inhibiting this specific pathway, the drug reduces the incidence of motion-induced vomiting.

Vanda had been subject to investigations over the long-term safety of the drug, but the company and the FDA agreed that motion sickness is an acute condition, so no-one should be taking this medication for extended periods of time.

The FDA based its decision on three clinical trials, two being Phase III real-word studies conducted on participants on boats. Nereus significantly reduced vomiting compared to a placebo.

Nereus is expected to be on pharmacy shelves within months, and will now be studied to see if it can pivot to also treat conditions such as gastroparesis and nausea linked to weight-loss medications.

Trial results were published in the journal Frontiers in Neurology.

Source: Vanda via PR Newswire

AFCON 2025: Senegal and Sudan set to face off – team news, start time, and lineups announced | Africa Cup of Nations updates

0

Who: Senegal vs Sudan
WhatCAF Africa Cup of Nations
Where: Ibn Batouta Stadium in Tangier
WhenSaturday, January 3, 5pm (16:00 GMT)
How to follow: We’ll have all the build-up on Al Jazeera Sport from 13:00 GMT in advance of our text commentary stream.

The AFCON round of 16 begins with a clash between the heavyweights and minnows, as title favourites Senegal face Sudan, the lowest-ranked side remaining in the competition.

Recommended Stories

list of 4 itemsend of list

Boasting considerable attacking firepower in Nicolas Jackson and Sadio Mane, Senegal stormed their way into the knockouts, affirming their place among the title favourites as the AFCON 2021 champions seek their second title.

The 117th-ranked Sudan, on the other hand, needed a helping hand to qualify and will play in the knockout stages for the first time in 14 years. Reaching the round of 16 represents a significant achievement for Sudan, whose footballing progress has defied ongoing turmoil at home.

Here’s everything you need to know about Senegal vs Sudan:

What’s going on in Sudan?

Sudan has been ravaged by war since fighting broke out between the Sudanese Armed Forces (SAF) and the paramilitary Rapid Support Forces (RSF) in April 2023.

The conflict has killed tens of thousands, displaced more than 12 million people and triggered famine in several parts of Sudan, a situation the United Nations has described as the “world’s worst humanitarian crisis”.

Sudan’s goalkeeper, Mohamed Abooja, had to deal with the anguish of his brother being taken prisoner by the RSF. “Of course, the team has been impacted. Everyone has just tried to get through this period, but it has been difficult with the tension all over Sudan,” Abooja told AFP news agency.

“In the end, our results on the pitch are what make the people happy and boost their morale.”

How did Sudan reach the 2025 AFCON round of 16?

Sudan’s team progressed to the last 16 as one of the four best third-placed teams, collecting three points in Group E courtesy of a 1-0 victory over Equatorial Guinea: a result that marked only their second-ever win at the tournament since lifting the trophy in 1970.

That historic victory was aided by a moment of good fortune, with an own goal from Equatorial Guinea’s Saul Coco proving decisive.

How did Senegal reach the round of 16?

Senegal, Africa’s second-highest-ranked nation at 19th in the world, finished top of Group D with seven points after two wins and a draw, edging DR Congo on goal difference.

They finished the group stage with the joint-second highest goal tally (seven, alongside Algeria), just one behind Nigeria.

Who will the winner face in the next round?

The winner of the Senegal and Sudan match will stay in Tangier to face the winner of the Mali and Tunisia match in the quarterfinals on January 9.

Who are Senegal’s best players?

Striker Nicolas Jackson made an impressive start with two goals in the opening match against Botswana, while Cherif Ndiaye also has two goals to his name – both scored after coming on as a substitute.

The experienced winger Sadio Mane is another star player of Senegal, alongside midfielders Iliman Ndiaye and Idrissa Gana Gueye.

Mane has been involved in 17 AFCON goals (10 goals, 7 assists), the most by any player since 2010.

Who are Sudan’s best players?

Midfielders Walieldin Khidir and Ammar Toaifour, along with defender Sheddy Barglan, have been Sudan’s standout performers at the tournament.

Senegal and Sudan form guides

All matches, most recent result last:

Senegal: W-D-W-W-L

Sudan: L-W-L-L-L

  • Senegal are on a 14-match unbeaten run at AFCON (W9 D5).
  • Senegal have kept 17 clean sheets at AFCON since 2017, more than any other team.
  • Sudan have conceded six goals, the most of any team to reach the round of 16.
  • Sudan won just one of their last seven AFCON matches (D1 L5).

Head-to-head

Senegal and Sudan have met in seven previous encounters, across competitive and friendly games.

Senegal boast an unbeaten record, having won four times and drawn three times.

When did Senegal and Sudan last meet?

The teams recently met in a 2026 FIFA World Cup qualifying match in September when Senegal won 2-0.

Senegal vs Sudan – stat attack

Saturday’s game will be their first meeting at AFCON and fifth overall in a span of a year.

Senegal have never lost to an East African opponent at AFCON, having played five matches, winning four and drawing one.

Have Senegal ever won an AFCON title?

This is Senegal’s 18th appearance at the AFCON finals, with their best result being the 2021 title they won in Cameroon. They have also finished runners-up twice: in 2002 and 2019.

Have Sudan ever won an AFCON title?

Sudan are making their 10th appearance this year. Since their debut in 1957, they have finished runners-up twice – in 1959 and 1963 – and won their only trophy in 1970.

Senegal captain Kalidou Koulibaly, a key member of their defence, will miss the match against Sudan after his sending off in the last match [File: Themba Hadebe/AP]

Senegal team news

Senegal coach Pape Thiaw will be without his captain, Kalidou Koulibaly, who is suspended for this match, having picked up a red card in their final group game.

Senegal’s predicted lineup

Edouard Mendy; Krepin Diatta, Abdoulaye Seck, Moussa Niakhate, Ismail Jakobs; Idrissa Gana Gueye, Pape Gueye; Ismaila Sarr, Iliman Ndiaye, Sadio Mane; Nicolas Jackson

Sudan team news

Sudan coach Kwesi Appiah will be without midfielders Salah Adil, Abo Eisa and Abuaagla Abdalla, who are injured.

Sudan’s predicted lineup

Monged El Neel; Sheddy Barglan, Mohamed Ereng, Mustafa Karshom, Bakhit Khamis; Walieldin Khidir, Abdelrazig Omer, Ammar Taifour; Aamir Abdallah, Mohammed Abdel-Rahman, Mohamed Eisa

Challenging the Client

0



Client Challenge



JavaScript is disabled in your browser.

Please enable JavaScript to proceed.

A required part of this site couldn’t load. This may be due to a browser
extension, network issues, or browser settings. Please check your
connection, disable any ad blockers, or try using a different browser.

Trump admits to exceeding doctors’ recommended daily dose of aspirin

0

US President Donald Trump says he is in “perfect” health, takes more aspirin than doctors recommend, uses makeup to cover bruising on his hands, and does not get regular exercise because he finds it “boring”.

In a lengthy interview about his health, Trump also told The Wall Street Journal that he underwent a CT scan in October, after incorrectly telling reporters that he had undergone a more detailed MRI scan.

Trump, 79, is the oldest president inaugurated in US history and his ageing has come under increased scrutiny.

He denied to the Journal that he has struggled to hear or that he has fallen asleep at recent White House events.

The newspaper said Trump “expressed irritation about the public debate over his health”.

“Let’s talk about health again for the 25th time,” the president said at the start of an “impromptu phone call” as the newspaper prepared to publish a story about his health.

Trump said he had been taking larger than recommended doses of aspirin for the last 25 years, even as he said it caused him to bruise easily.

“They say aspirin is good for thinning out the blood, and I don’t want thick blood pouring through my heart,” Trump said.

He takes 325mg of aspirin per day, rather than the 81mg dose sometimes recommended by doctors.

“They’d rather have me take the smaller one,” Trump said.

But he does not want to switch routines after so many years. “I’m a little superstitious,” he said.

According to guidance from the Mayo Clinic, the risk of heart attack and stroke goes up as you get older and low-dose aspirin helps to prevent both by thinning the blood and preventing clots. But the clinic warns that the risk of bleeding from aspirin also goes up with age. It says the daily dose for aspirin therapy is between 75mg and 325mg.

The president also talked about the medical scan he received at Walter Reed National Medical Center, which he previously said was an MRI scan.

“It wasn’t an MRI,” Trump told the Journal. “It was less than that. It was a scan.”

A doctor for Trump, Navy Capt Sean Barbabella, said in a statement provided to the Journal that Trump had undergone a CT scan, “to definitively rule out any cardiovascular issues” and that the testing revealed no abnormalities.

After Trump was diagnosed with chronic venous insufficiency, a common condition in older people, he was advised to wear compression socks but he declined.

“I didn’t like them,” Trump said, adding that he now gets up from his desk more regularly, which has improved swelling in his legs.

Still, the president said he preferred not to do any form of regular exercise, other than golfing.

“I just don’t like it. It’s boring,” Trump said. “To walk on a treadmill or run on a treadmill for hours and hours like some people do, that’s not for me.”

The president maintained that he had not nodded off during public meetings, saying he closed his eyes at times because he finds it “relaxing”. As for the bruising seen on his hands in some photos, Trump said he now carried makeup in case his hand got “whacked”.

“I have makeup that’s, you know, easy to put on, takes about 10 seconds,” he said.

Trump said he did not have trouble with his hearing, and when photographers have taken photos of him when he appears to be sleeping, he said “sometimes they’ll take a picture of me blinking”.

“And they’ll catch me with the blink.”

Barbabella said in the statement to the Journal that Trump was in “exceptional health and perfectly suited to execute his duties as Commander in Chief”.

Trump’s predecessor, Democratic President Joe Biden, dropped out of the 2024 election race after a stumbling debate with Trump raised questions about his age and mental sharpness.

Teen Describes Dramatic Escape from Lethal Swiss Fire

0

new video loaded: Teen Recounts Escape from Deadly Swiss Fire

People gathered at memorials in the resort town of Crans-Montana, Switzerland, to grieve for the victims of a deadly New Year’s fire at a bar. A survivor described her harrowing escape.

By Shawn Paik

January 2, 2026

Zohran Mamdani sworn in as New York City’s mayor with Quran for the first time in history

0

Incoming Mayor Zohran Mamdani took his midnight oath of office on a centuries-old Quran, marking the first time a mayor of New York City uses Islam’s holy text to be sworn in and underscoring a series of historic firsts for the city.

The 34-year-old Democrat became mayor in a long-closed subway station beneath City Hall, the first Muslim, first South Asian and first African-born person to hold that position.

These milestones — as well as the historical Quran — reflect the longstanding and vibrant Muslim residents of the nation’s most populous city, according to a scholar who helped Mamdani’s wife, Rama Duwaji, select one of the books.

Most of Mamdani’s predecessors were sworn in on a Bible, although the oath to uphold the federal, state and city constitutions does not require the use of any religious text.

And while he has focused heavily on the issue of affordability during his campaign, Mamdani was outspoken about his Muslim faith. He frequently appeared at mosques across the five boroughs as he built a base of support that included many first-time South Asian and Muslim voters.

A look at the three Qurans that Mamdani used

Two Qurans were to be used during the subway ceremony: his grandfather’s Quran and a pocket-sized version that dates back to the late 18th or early 19th century. It is part of the collection at the New York Public Library’s Schomburg Center for Research in Black Culture.

That copy of the Quran symbolizes the diversity and reach of the city’s Muslims, said Hiba Abid, the library’s curator for Middle Eastern and Islamic Studies.

“It’s a small Quran, but it brings together elements of faith and identity in New York City history,” Abid said.

For a subsequent swearing-in ceremony at City Hall on the first day of the year, Mamdani will use both his grandfather’s and grandmother’s Qurans. The campaign hasn’t offered more details on those heirlooms.

One Quran’s long journey to Mamdani’s hand

The manuscript was acquired by Arturo Schomburg, a Black Puerto Rican historian whose collection documented the global contributions of people of African descent. While it is unclear how Schomburg came into possession of the Quran, scholars believe it reflected his interest in the historical relationship between Islam and Black cultures in the United States and across Africa.

Unlike ornate religious manuscripts associated with royalty or elites, the copy of the Quran that Mamdani will use is modest in design. It has a deep red binding with a simple floral medallion and is written in black and red ink. The script is plain and readable, suggesting it was created for everyday use rather than ceremonial display.

Those features indicate the manuscript was intended for ordinary readers, Abid said, a quality she described as central to its meaning.

“The importance of this Quran lies not in luxury, but in accessibility,” she said.

Because the manuscript is undated and unsigned, scholars relied on its binding and script to estimate when it was produced, placing it sometime in the late 18th or early 19th century during the Ottoman period in a region that includes what is now Syria, Lebanon, Israel, the Palestinian territories and Jordan.

Abid said the manuscript’s journey to New York mirrors Mamdani’s own layered background. Mamdani is a South Asian New Yorker who was born in Uganda, while Duwaji is American-Syrian.

Identity and controversy

The meteoric rise of a Muslim democratic socialist also brought a surge of Islamophobic rhetoric, amplified by national attention on the race.

In an emotional speech days before the election, Mamdani said the hostility had only strengthened his resolve to be visible about his faith.

“I will not change who I am, how I eat, or the faith that I’m proud to call my own,” he said. “I will no longer look for myself in the shadows. I will find myself in the light.”

The decision to use a Quran has drawn fresh criticism from some conservatives. U.S. Sen. Tommy Tuberville of Alabama wrote on social media, “The enemy is inside the gates,” in response to a news article about Mamdani’s inauguration. The Council on American-Islamic Relations, a civil-rights group, has designated Tuberville as an anti-Muslim extremist based on past statements.

Such backlash is not new. In 2006, Keith Ellison, the first Muslim elected to Congress, faced condemnation from conservatives after he chose to use a Quran for his ceremonial oath.

Following the inauguration, the Quran will go on public display at the New York Public Library. Abid said she hopes attention surrounding the ceremony — whether supportive or critical — will prompt more people to explore the library’s collections documenting Islamic life in New York, ranging from early 20th century Armenian and Arabic music recorded in the city to firsthand accounts of Islamophobia after the Sept. 11 attacks.

“This manuscript was meant to be used by ordinary readers when it was produced,” Abid said. “Today it lives in a public library where anyone can encounter it.”

___

Associated Press writers Jake Offenhartz in New York and Kim Chandler in Montgomery, Alabama, contributed.

This story was originally featured on Fortune.com

Maduro expresses willingness to engage in dialogue with US, stays silent on dock incident | Political News

0

Venezuela leader strikes conciliatory tone while renewing claim US wants to topple government to access vast oil reserves.

Venezuela is open to negotiating a deal with the United States to combat drug trafficking, President Nicolas Maduro has said, even as he remained silent on a reported CIA-led strike on his country last week.

The latest statement, made during an interview that aired on Thursday, comes as Maduro has struck a more conciliatory tone towards the US amid Washington’s months-long sanctions and military pressure campaign.

Recommended Stories

list of 3 itemsend of list

That included, on Thursday, the release of more than 80 prisoners accused of protesting his disputed victory in the 2024 election, the second such release in recent days.

“Wherever they want and whenever they want,” Maduro told Spanish journalist Ignacio Ramonet of the idea of dialogue with the US on drug trafficking, oil and migration in an interview on state TV.

He stressed that it is time for both nations to “start talking seriously, with data in hand”.

“The US government knows, because we’ve told many of their spokespeople, that if they want to seriously discuss an agreement to combat drug trafficking, we’re ready,” he said.

Still, Maduro renewed his allegations that the US is trying to topple his government and gain access to Venezuela’s vast oil reserves through Washington’s months-long sanctions and military pressure campaign.

“If they want oil, Venezuela is ready for US investment, like with Chevron,” he added, referring to the US oil giant, which is the only major oil company exporting Venezuelan crude to the US.

Asked point-blank by Ramonet if he confirmed or denied a US attack on Venezuelan soil, Maduro said: “This could be something we talk about in a few days.”

To date, Maduro has not confirmed a US land attack on a docking facility that allegedly targeted drug boats.

For months, the US has launched numerous strikes on alleged drug smuggling boats originating from Venezuela, in what rights groups have decried as extrajudicial killings. The Trump administration has also imposed a blockade on sanctioned oil tankers entering and exiting Venezuela’s coast.

Tensions further escalated after Trump revealed earlier this week a strike on a docking area for alleged Venezuelan drug boats, in the first known attack on Venezuelan territory of the US campaign.

Trump has not confirmed widespread reports in US media that the attack was a CIA operation or where it occurred, saying only it was “along the shore”.

“There was a major explosion in the dock area where they load the boats up with drugs,” he told reporters at his Mar-a-Lago resort in Florida.

“So we hit all the boats and now we hit the area, it’s the implementation area, that’s where they implement. And that is no longer around.”

The US president has repeatedly threatened ground strikes on drug cartels in the region, which he has labelled “narcoterrorists”. He has claimed, without providing evidence, that Maduro leads a trafficking organisation that aims to destabilise the US by flooding it with drugs.

However, regional experts have noted that Venezuela is not known to be involved in the illicit fentanyl trade, which far and away accounts for the highest number of overdose deaths in the US. Trump has labelled the drug a “weapon of mass destruction”.

Maduro has said the Trump administration’s approach makes it “clear” that the US “seek to impose themselves” on Venezuela through “threats, intimidation and force”.

Maduro’s interview was taped on New Year’s Eve, the same day the US military struck five alleged drug-smuggling boats, killing at least five people.

The latest attacks bring the total number of known boat strikes in the Caribbean and eastern Pacific to 35 and the number of people killed to at least 115, according to numbers announced by the Trump administration.

Venezuelans and Colombians have been among the victims.

Client Challenge: Overcoming Obstacles and Achieving Success

0



Client Challenge



JavaScript is disabled in your browser.

Please enable JavaScript to proceed.

A required part of this site couldn’t load. This may be due to a browser
extension, network issues, or browser settings. Please check your
connection, disable any ad blockers, or try using a different browser.

Protesters and security forces clash in Iran, resulting in six deaths

0

Growing unrest in Iran is reported to have claimed more lives on a fifth day of protests over the soaring cost of living.

Both the semi-official Fars news agency and human rights group, Hengaw, said two people had died during clashes between protesters and security forces in the city of Lordegan, in south-western Iran. Three more people were killed in Azna and another in Kouhdasht, Fars reported, all in the west of the country.

On Thursday videos posted on social media showed cars set on fire during running battles between protesters and security forces.

Many protesters have called for ending the rule of the country’s supreme leader. Some have also called for a return to the monarchy.

As the day wore on more reports came in of unrest up and down the country, on the fifth day of the protests, sparked by a currency collapse.

Videos verified by BBC Persian show protests in the central city of Lordegan, the capital Tehran and Marvdasht in the southern Fars province taking place on Thursday.

Fars reported that in Lordegan two people were killed, citing an informed official. The report did not specify whether those killed were protesters or members of the security forces. It also reported the three deaths in Azna, in neighbouring Lorestan province, without specifying if there were protesters or security officials.

Rights group Hengaw said the two killed in Lordegan were protesters, naming them as Ahmad Jalil and Sajjad Valamanesh.

BBC Persian has not been able to independently verify the deaths.

Separately state media said a member of the security forces linked to Iran’s Revolutionary Guards (IRGC) was killed in clashes with protesters on Wednesday night in the city of Kouhdasht, in the western Lorestan province.

The BBC has not been able to verify this and protesters say the man was one of their number and was shot dead by the security forces.

A further 13 police officers and Basij members were injured by stone throwing in the area, the state media report said.

Schools, universities and public institutions were closed across the country on Wednesday after a bank holiday was declared by authorities in an apparent effort to quell the unrest.

It was ostensibly to save energy because of the cold weather, though it was seen by many Iranians as an attempt to contain the protests.

They began in Tehran – among shopkeepers angered by another sharp fall in the value of the Iranian currency against the US dollar on the open market.

By Tuesday, university students were involved and they had spread to several cities, with people chanting against the country’s clerical rulers.

The protests have been the most widespread since an uprising in 2022 sparked by the death in custody of Mahsa Amini, a young woman who was accused by morality police of not wearing her veil properly. But they have not been on the same scale.

To prevent any escalation, tight security is now reported in the areas of Tehran where the demonstrations began.

President Masoud Pezeshkian has said his government will listen to the “legitimate demands” of the protesters.

But the prosecutor general, Mohammad Movahedi-Azad, has also warned that any attempt to create instability would be met with what he called a “decisive response”.